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Figure 1 | Retrovirology

Figure 1

From: Human Cytomegalovirus (HCMV) induces Human Endogenous Retrovirus (HERV) transcription

Figure 1

Effects of HCMV on the activity of Mn2+-dependent RT and HERV transcription profile in human cancer cell lines. A, B: RT activity in glioma initiating cells GliNS1 (A) and G179NS (B) 5 days post infection with 1 MOI HCMV strain VR 1814 or TB40/F; D, E: RT activity in prostate cancer cells PC3 (E) and LNCaP (D); C: RT activity in glioma cell line U373 5 days post infection with 1 MOI HCMV strain VR 1814 or TB40/F; means and standard deviation of 5 independent experiments F: One representative example of false-colour microarray data sets representing uninfected and HCMV - infected (VR 1814, MOI 1, 7 dpi) samples. Detailed information about the identity of microarray capture probes has been described previously [26, 27] and can be found in the (Additional file 1). Each positive spot on the microarray represents multiple HERV loci assigned to one subgroup of multicopy HERV elements with sufficient sequence homology. The housekeeping genes upiquitin, GAPD, RPL19 and HPRT served as an internal control. Differences between uninfected and infected cells are indicated by red boxes. **p = <0.01.

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