Figure 1
From: Contribution of oligomerization to the anti-HIV-1 properties of SAMHD1
SAMHD1 dimer interface is stabilized by hydrophobic interactions. (A) SAMHD1 dimer as observed in the crystal structure (PDB ID: 3U1N) [29]. The extensive dimer interface is stabilized by two hydrophobic patches formed by residues Y146, Y154, L428 and Y432 shown in green and magenta. (B) The close-up view showing the packing of the four hydrophobic residues at the interface. The two patches are related by the 2-fold rotational symmetry of the dimer.