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Figure 5 | Retrovirology

Figure 5

From: S100A9 protein is a novel ligand for the CD85j receptor and its interaction is implicated in the control of HIV-1 replication by NK cells

Figure 5

Anti-HIV-1 activity of NK cell stimulated by S100A9 monomer or tetramer proteins. MDDC or CD4+ T cells were infected by HIV-1 and then cultured with unstimulated, S100A9 monomer- or S100A9 tetramer-stimulated NK cells (black, grey and white bars respectively) at the ratio E/T of 1:5. (A-B) HIV-1 replication was measured by intracellular p24 expression in MDDC and CD4+ T cells after 7 and 10 days of culture. (A) Graph represents cumulative results from 4 independent experiments showing the percentage of p24+ MDDC. (B) Graph represents cumulative results from 8 independent experiments showing the percentage of p24+ CD4+ T cells. (C) Graph represents cumulative results from 6 independent experiments showing the amount of p24 HIV-1 antigen in the supernatant of HIV-1-infected CD4+ T cells in culture with unstimulated, S100A9 monomer- or S100A9 tetramer-stimulated NK cells (black, grey and white bars respectively). For blocking experiments, NK cells were stimulated with an equimolar combination of CD85j-Fc + S100A9 tetramer. Results are expressed as mean ± SE and p values are shown.

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