There is sustained HIV replication in TOM that can be efficiently suppressed by ART. A) Sustained levels of plasma HIV-RNA in infected TOM (n = 5). B) The plasma viral load of infected TOM (n = 4) pre- and post-initiation of ART treatment demonstrated the ability of ART to suppress viremia in these mice. ART consisted of daily injections of TDF, FTC and Raltegravir. C) Plasma viral load from an infected TOM dropped below the limit of detection and remained undetectable for the duration of ART. As seen in humans, viremia rebounded following treatment interruption. The limit of detection of the assay is indicated with a dashed line. Error bars in both graphs represent the Mean ± SEM.