Figure 3

Proposed model explaining the memory effect of M48U1 through gp120 shedding. M48U1 induces shedding of gp120 from HIV envelope proteins embedded in the membrane of infected cells prior to budding. This results in the production of defective virions in absence of drug during the first 24 h post treatment. Continuous recruitment of new envelope proteins from the endoplasmic reticulum to the cell membrane explains why infectivity is restored over-time.