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Figure 6 | Retrovirology

Figure 6

From: Characterization of simian T-cell leukemia virus type 1 in naturally infected Japanese macaques as a model of HTLV-1 infection

Figure 6

Clonal proliferation of STLV-1-infected cells and lymphomatous lesion in the STLV-1-infected Japanese macaque. (A) The relative frequency of STLV-1+ clones in three monkeys (Mf-1, Mf-2 and Mf-3) is presented. Each area in the pie charts represents the proportion of provirus in a separate clone (identified by its unique integration site). (B) Flow cytometric analysis of PBMCs from an STLV-1-infected monkey shows that Tax-expressing cells are positive for CD4. (C) Magnetic resonance imaging of the brain of monkey Mf-4. The lesion is indicated by the white arrow. (D) Immunohistochemical analyses show that lymphoma cells are positive for CD3 and CD4. (E) Relative abundance of STLV-1+ clones identified by unique integration sites of the provirus in PBMCs (left) and in the brain lesion (right) of Mf-4. Some of the abundant clones that are observed both in PBMCs and the brain lesion are painted in the same color in the two pie charts. (F) STLV-1+ abundant clone 13[+]40177103 is detected in the brain lesion by using the primers for 3’ LTR and the genomic region, but not in PBMCs.

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