Skip to main content
Figure 4 | Retrovirology

Figure 4

From: Characterization of simian T-cell leukemia virus type 1 in naturally infected Japanese macaques as a model of HTLV-1 infection

Figure 4

Effects of STLV-1 Tax and SBZ on various signaling pathways. Effects of HTLV-1 Tax or STLV-1 Tax (A), and HBZ or SBZ (B) were analyzed using reporter plasmids for the NFAT, AP-1 and NF-κB pathways in Jurkat cells. (C) The effects of HTLV-1 Tax or STLV-1 Tax (left) and HBZ or SBZ (right) on the TGF-β signaling pathway were analyzed in HepG2 cells using the reporter plasmid 3TP-Lux, which contains the responsive element to Smad3/4. (D) The effects of HTLV-1 Tax or STLV-1 Tax (left) and HBZ or SBZ (right) on relative luciferase activity driven by TCF-responsive elements were analyzed using Jurkat cells. (E) The effects of HTLV-1 Tax or STLV-1 Tax (left) and HBZ or SBZ (right) on relative luciferase activity driven by viral LTR were analyzed using Jurkat cells. Firefly luciferase activity was normalized to that of Renilla luciferase and represented as fold activation compared to the relevant control. The data represent mean and standard deviation.

Back to article page

Retrovirology

ISSN: 1742-4690

Contact us