Figure 4

Dominant and Non-dominant T Cell Response Reproducibility. Of the 32 peptides that elicited a T cell response at 52 WPI within a given MHC-matched group, 22 induced a response that was dominant in at least one animal within the same MHC class I haplotype. The proportion of animals mounting a response against these peptides was significantly greater than proportion of animals within an MHC-matched group that mounted a response against a peptide that did not elicit a dominant response in any animals with that class I haplotype (P < 0.05). Responses were detected by full proteome pooled peptide matrix ELISPOT at 52 WPI. Lines represent the mean proportion of animals within an MHC-matched group responding to target region and error bars represent the standard error of the mean.