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Figure 2 | Retrovirology

Figure 2

From: Genetic diversity of the highly variable V1 region interferes with Human Immunodeficiency Virus type 1 envelope functionality

Figure 2

Functionality of the V1V2 chimeric envelopes in viral entry tests. Panel A. Functionality of the V1V2 chimeras. The level of functionality of the V1V2 chimeras in viral entry tests for the main 5 chimeras characterized in this study is given relative to the functionality of the wild-type receiver protein (Env from the isolate of subtype A for the ABA, ACA, and AGA chimeras, and from subtype B for BCB and BGB chimeras). Values are the average of 4 to 5 independent experiments. The asterisk indicates a significant difference (p < 0.001) in the functionality of the chimera with respect to the corresponding wild-type receiver protein. Panel B . Functionality of V1V2 intra- and intersubtype chimeras. The functionality of six intrasubtype (gray circles) and six intersubtype (white circles) chimeras is given relative to the functionality of the corresponding wild-type receiver Env. Thicker circles indicate significant differences (p < 0.001) in the functionality of the chimera with respect to the corresponding wild-type receiver protein. Values are the average of 3 to 5 independent experiments. Details regarding the sequences used for this part of the study are given in the Methods section.

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