Figure 3

Antiviral activity in NHP CVL. TZM-bl cells were challenged with approximately 10³ TCID₅₀ HIV-1_Ba-L in the presence of 1:10 (A) or 1:100 (B) dilutions of CVL collected from pig-tailed macaques at Day 0 (baseline) and 7 and 14 days post-insertion of IVR. Four animals were exposed to IVRs loaded with 10% (w/w) IQP-0528 (squares) and two animals received placebo IVRs (circles). HIV infection was assessed by measuring luciferase activity 48 h post-challenge. Data are presented as the percent inhibition relative to control cells challenged in the absence of CVL and are means obtained from two independent experiments where each condition was tested in triplicate. The line indicates the mean for the group.