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Figure 4 | Retrovirology

Figure 4

From: Evolution of the human immunodeficiency virus type 2 envelope in the first years of infection is associated with the dynamics of the neutralizing antibody response

Figure 4

Evolution of V1 and V3 regions. Clonal V1 and V3 amino acid sequences obtained over the course of infection from child 1 (panel A) and child 2 (panel B) were aligned against consensus sequences from the initial infecting isolate. Dots in the alignments indicate sequence identity to the consensus; dashes indicate deletions. Potential N-linked glycans (occurring at NXT/S) are represented in open boxes. Amino acids highlighted in light grey are involved in tropism change [36]. Blue boxes in the consensus sequence represent published linear neutralizing epitopes in V1 [28] and V3 [26]; red boxes in the consensus sequence represent a conformational epitope in V3 [26]. Viral tropism is indicated at the right of the alignment as determined phenotypically or genotypically based on V3 loop sequence patterns. Black arrows signal fixed mutations.

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