Figure 5
From: Expression profile of host restriction factors in HIV-1 elite controllers
Elevated expression of restriction factor genes in HIV-1 elite controllers with respect to ART-suppressed individuals. Five restriction factors were significantly elevated in elite controllers with respect to ART-suppressed subjects: (A) APOBEC3C, (B) APOBEC3D, (C) CTR9, (D) TRIM26, and (E) TRIM32. Gene expression between groups was compared using unpaired t tests. (F) The expression of CDKN1A/p21 was positively correlated with CD4+ T cell activation in elite controllers. There were no correlations between gene expression and activation in ART-suppressed individuals. Correlations were evaluated using Pearson’s r tests.