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Table 2 Studies of passive immunization in newborn macaques

From: The role of neutralizing antibodies in prevention of HIV-1 infection: what can we learn from the mother-to-child transmission context?

Treatment Challenge Sterile protection References
Antibody (Route, Concentration) Infusion timing Virus Route
SIV hyperimmune serum (SC, 20 mL/kg) - Postnatal 2 days before challenge SIVmac 251 (105 TCID50) Oral - 2/2 [1]
- Postnatal 2 days before challenge and 5 and 12 days after challenge - 4/4
- Postanatal 3 weeks after challenge - 0/3
- HIV immune globin (HIVIG) (IV, 400 mg/kg) Postnatal 24 hours before challenge SHIV89.6PD (40 TCID50) IV - 0/3 [3]
- 2F5 (IV, 15 mg/kg) - 0/3
- 2G12 (IV, 15 mg/kg) - 0/3
- 2F5 / 2G12 (IV, 15 mg/kg of each) - 0/3
- HIVIG/2F5/2G12 (IV, 400 mg/kg of HIVIG, 15 mg/kg of each HuMoNAb) - 3/6
F105/2G12/2F5 (IV, 10 mg/kg of each) Pre- and postnatal 1–4 hours before and 8 days after challenge SHIVIIIB-vpu+ (10 AID50) Oral 4/4 [4]
2G12/b12/2 F5 (IV, 10 mg/kg of each) Postnatal 1 hour before and 8 days after challenge - SHIVIIIB-vpu+ (10 AID50) Oral - 2/2 [148]
- SHIV-89.6P (15 AID50) - 1/4
F105/2G12/2F5 (IV, 10 mg/kg of each) - Postnatal 3–4 hours before challenge and 8 days after challenge SHIVIIIB-vpu+ (10 AID50) Oral - 2/2 [149]
- Postnatal 1 hour and 8 days after challenge - 2/2
2G12/b12/2F5/4E10 (IV, 30 mg/kg of each except 4E10 at 11.5 mg/kg) Postnatal 1 hour and 8 days after challenge SHIV-89.6P (15 AID50) Oral 2/4 [6]
2G12/2F5/4E10 (IM, 40 mg/kg of each) Postnatal 1 hour and 8 days after challenge SHIV-89.6P (15 AID50) Oral 4/4 [150]
- 2G12/b12/2 F5/4E10 (IV, 30 mg/kg of each) - Postnatal 1 hour and 8 days after challenge SHIV-89.6P (15 AID50) Oral - 3/4 [151]
- Post natal 12 hours and 8 days after challenge - 1/4
- 2G12/2F5/4E10 (IM, 40 mg/kg of each) - Postnatal 24 hours and 9 days post challenge - 0/4
  1. TCID50: 50% tissue culture infectious dose; AID50: 50% animal infectious dose.
  2. SC: subcutaneous; IV: intravenous; IM: intramuscular.