Treatment | Challenge | Sterile protection | References | ||
---|---|---|---|---|---|
Antibody (Route, Concentration) | Infusion timing | Virus | Route | ||
SIV hyperimmune serum (SC, 20 mL/kg) | - Postnatal 2 days before challenge | SIVmac 251 (105 TCID50) | Oral | - 2/2 | [1] |
- Postnatal 2 days before challenge and 5 and 12 days after challenge | - 4/4 | ||||
- Postanatal 3 weeks after challenge | - 0/3 | ||||
- HIV immune globin (HIVIG) (IV, 400 mg/kg) | Postnatal 24 hours before challenge | SHIV89.6PD (40 TCID50) | IV | - 0/3 | [3] |
- 2F5 (IV, 15 mg/kg) | - 0/3 | ||||
- 2G12 (IV, 15 mg/kg) | - 0/3 | ||||
- 2F5 / 2G12 (IV, 15 mg/kg of each) | - 0/3 | ||||
- HIVIG/2F5/2G12 (IV, 400 mg/kg of HIVIG, 15 mg/kg of each HuMoNAb) | - 3/6 | ||||
F105/2G12/2F5 (IV, 10 mg/kg of each) | Pre- and postnatal 1–4 hours before and 8 days after challenge | SHIVIIIB-vpu+ (10 AID50) | Oral | 4/4 | [4] |
2G12/b12/2 F5 (IV, 10 mg/kg of each) | Postnatal 1 hour before and 8 days after challenge | - SHIVIIIB-vpu+ (10 AID50) | Oral | - 2/2 | [148] |
- SHIV-89.6P (15 AID50) | - 1/4 | ||||
F105/2G12/2F5 (IV, 10 mg/kg of each) | - Postnatal 3–4 hours before challenge and 8 days after challenge | SHIVIIIB-vpu+ (10 AID50) | Oral | - 2/2 | [149] |
- Postnatal 1 hour and 8 days after challenge | - 2/2 | ||||
2G12/b12/2F5/4E10 (IV, 30 mg/kg of each except 4E10 at 11.5 mg/kg) | Postnatal 1 hour and 8 days after challenge | SHIV-89.6P (15 AID50) | Oral | 2/4 | [6] |
2G12/2F5/4E10 (IM, 40 mg/kg of each) | Postnatal 1 hour and 8 days after challenge | SHIV-89.6P (15 AID50) | Oral | 4/4 | [150] |
- 2G12/b12/2 F5/4E10 (IV, 30 mg/kg of each) | - Postnatal 1 hour and 8 days after challenge | SHIV-89.6P (15 AID50) | Oral | - 3/4 | [151] |
- Post natal 12 hours and 8 days after challenge | - 1/4 | ||||
- 2G12/2F5/4E10 (IM, 40 mg/kg of each) | - Postnatal 24 hours and 9 days post challenge | - 0/4 |