The role of neutralizing antibodies in prevention of HIV-1 infection: what can we learn from the mother-to-child transmission context?

Table 1 Studies of the viral population of HIV-1 infected infants

Infant samples			Infection route	Homo-/heterogeneous population ratio	References
Nature	Collection time*	Amplified *env*region	Infection route	Homo-/heterogeneous population ratio	References
PBMCs	2 to 4 months	V3 and V4-V5	Unspecified	3/0	[61]
PBMCs	Unspecified	V3 and V4-V5	Unspecified	4/0	[68]
PBMCs and serum	0 to 4 months	V3	1 IU, 9 unknown	8 (1 IU)/2	[69]
Serum	At birth	V3	1 IU	1/0	[70]
PBMCs	0 to 12.5 months	V3	1 IU, 4 unknown	2/3 (1 IU)	[71]
PBMCs	2 days to 7 weeks	V1-V2-C2	Unspecified	1/2	[72]
PBMCs	1 week to 34 months	V3	Unspecified	7/0	[73]
PBMCs	5 days to 1.5 months	V3	Probably 1 PN, 3 IU	1 (PN)/3 (IU)	[74]
PBMCs and plasma	2 to 40 days	C2-V3	Unspecified	3/1	[75]
PBMCs	1 month	V3	Unspecified	13/4	[76]
Plasma	48 hours or 2 to 6 weeks	V3-V5	9 PN, 14 IU	17 (7 PN, 10 IU)/6 (2 PN, 4 IU)	[77]
PBMCs	0 or 2 to 6 months	C2-V4	3 PN or early PP, 1 IU	3 (2 PN, 1 IU)/1	[78]
PBMCs	0 or 6 weeks	V1-V4	7 PN or early PP, 6 IU	6 (2 IU, 4 PN)/7 (4 IU, 3 PN)	[79]
PBMCs	48 hours or 2 to 6 weeks	V3-V5	7 PN, 14 IU	15 (5 PN, 10 IU)/6 (2 PN, 4 IU)	[80]
PBMCs or plasma	6 weeks	V1-V5	8 PN or early PP, 1 IU, 3 BF	11/1 (PN)	[81]
PBMCs or cord blood	0 or 6 to 15 months	V1-V3	3 PP, 1 IU	4/0	[82]
PBMCs	4 to 18 months	V1-V5	Unspecified	0/3	[83]
Plasma	0 or 6 weeks	V1-V2	23 PN, 25 IU	20 (6 PN, 14 IU)/28 (17 PN, 11 IU)	[84]
Plasma	48 hours or 6 weeks	V1-V5	11 PN, 6 IU	14 (9 PN, 5 IU)/3 (2 PN, 1 IU)	[85]
PBMCs	2 to 4 months	V1-V5	6 PN or early PP	5/1	[86]
Plasma	30 to 66 days	V1-V5	5 PN	3/2	[87]
Plasma	0 or 6 weeks	V1-V5	9 PN or early PP, 10 IU	13 (5 PN, 8 IU)/6 (4 PN, 2 IU)	[88]
Plasma	3 or 6 months	complete env	2 PP	2/0	[89]
				total: 156/235

ISSN: 1742-4690