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Figure 5 | Retrovirology

Figure 5

From: HIV-1 envelope glycoprotein signatures that correlate with the development of cross-reactive neutralizing activity

Figure 5

Sensitivity to bNAbs does not correlate with the induction of cross-reactive neutralizing activity. Sensitivity to neutralization by b12, VRC01, 447-52D, 2G12, PGT121, PGT126, PG9, PG16, PGT145, 2F5 and 4E10 and polyclonal HIVIg (three different sera pools) of viral variants obtained from 12 individuals who developed CrNA (grey bars) and 9 individuals who did not develop CrNA (white bars). Median IC50 values per individual per bNAb or HIVIg as determined by linear regression are used and differences were considered statistically significant when P values were ≤ 0.05, represented by an asterix. The bNAbs are ordered from left to right according to their epitope cluster.

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