Figure 2

Short V1 sequences and lower probability of overall glycosylation correlate with the development of cross-reactive neutralizing activity. Scatter plots of individual’s geometric mean IC₅₀ titer across the 6 virus panel (x-axis) versus sequence characteristics of the gp160s from clonal virus isolates on the y-axis. (A) length of gp160 in amino acids (AA); (B) length of variable region 1 (V1) in amino acids (AA); (C) total number of PNGS in gp160; (D) number of NXS motifs relative to the total number of PNGS.