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Table 2 Linear regression models investigating the relationship between Nef function and socio-demographic characteristics, clinical parameters and HIV-1 subtype

From: Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes

Variable Univariate (CD4) Multivariable (CD4)a Univariate (HLA-I) Multivariable (HLA-I)b
Estimate p-value Estimate p-value Estimate p-value Estimate p-value
Subtype A -0.060 0.02 -0.048 0.06 -0.14 <0.0001 -0.16 <0.0001
B 0 N/A 0 N/A 0 N/A 0 N/A
C -0.072 0.007 -0.051 0.07 -0.21 <0.0001 -0.24 <0.0001
D -0.028 0.3 -0.012 0.7 -0.13 <0.0001 -0.16 <0.0001
Log viral load 0.040 0.002 0.033 0.02 0.050 0.003 - -
Log CD4 -0.009 0.7 - - -0.013 0.6 - -
Male 0.026 0.2 - - 0.057 0.02 -0.06 0.06
Age -0.0006 0.6 - - 0.000001 0.94 - -
  1. β Estimates for log viral load and log CD4 count are expressed per log10 increment. Age is expressed per year increment. For sex, female is the reference group. For HIV-1 subtype, B is the reference group.
  2. aMultivariable model for CD4 downregulation: multiple r2 = 0.045, p = 0.006.
  3. bMultivariable model for HLA-I downregulation: multiple r2 = 0.14, p < 0.0001.