Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes

Retrovirology

Table 2 Linear regression models investigating the relationship between Nef function and socio-demographic characteristics, clinical parameters and HIV-1 subtype

Variable		Univariate (CD4)		Multivariable (CD4)^a		Univariate (HLA-I)		Multivariable (HLA-I)^b
Variable		Estimate	p-value	Estimate	p-value	Estimate	p-value	Estimate	p-value
Subtype	A	-0.060	0.02	-0.048	0.06	-0.14	<0.0001	-0.16	<0.0001
	B	0	N/A	0	N/A	0	N/A	0	N/A
	C	-0.072	0.007	-0.051	0.07	-0.21	<0.0001	-0.24	<0.0001
	D	-0.028	0.3	-0.012	0.7	-0.13	<0.0001	-0.16	<0.0001
Log viral load		0.040	0.002	0.033	0.02	0.050	0.003	-	-
Log CD4		-0.009	0.7	-	-	-0.013	0.6	-	-
Male		0.026	0.2	-	-	0.057	0.02	-0.06	0.06
Age		-0.0006	0.6	-	-	0.000001	0.94	-	-

β Estimates for log viral load and log CD4 count are expressed per log₁₀ increment. Age is expressed per year increment. For sex, female is the reference group. For HIV-1 subtype, B is the reference group.
^aMultivariable model for CD4 downregulation: multiple r² = 0.045, p = 0.006.
^bMultivariable model for HLA-I downregulation: multiple r² = 0.14, p < 0.0001.

ISSN: 1742-4690