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Table 1 Examples of cellular factors inhibiting early steps of retroviral cycle.

From: Early steps of retrovirus replicative cycle

  Restricted Retrovirusesa Step being affectedb Viral determinantc Distribution Cloned
CEM15 HIV-1 RT Vif human yes
Fv1 N-MLV or B-MLV between RT and integration CA Mouse yes
Ref1 N-MLV, EIAV between entry and RT CA various mammals yes*
Lv1 N-MLV, HIV-1, HIV-2, SIVmac, EIAV between entry and RT CA various mammals yes
Lv2 HIV-2 between RT and nuclear entry CA / Env human no
  1. Abbreviations: a HIV-1, human immunodeficiency virus type 1 ; HIV-2, human immunodeficiency virus type 2 ; SIVmac, simian immunodeficiency virus macaques ; N-MLV, N-tropic murine leukemia virus ; B-MLV, B-tropic murine leukemia virus ; EIAV, equine infectious anemia virus. b RT, reverse-transcription. c CA, capsid protein ; Env, envelope glycoproteins. *Personal communications and unpublished data.