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Table 1 Relation between AIDS clinical courses and nef dsRNA or siRNA/miRNA in suppression of nef gene expression

From: HIV-1 nef suppression by virally encoded microRNA

Nef inhibitor Nef expressed by: Target region Clinical courses
  Nef-EGFP HIV-1 IIIB PFV/nef   
dsRNA *      Human
SF2 ++ † ++ ND‡ Full-length (including miR-N367) ND
1-3-3 ++ - ND U3 deleted Rapid progressor, Died within 3 years
4-2-1 ND + ND U3 region (including miR-N367) Rapid progressor, Died within 3 years
15-2-2 ++ +++ ND U3 region (including miR-N367) Non progressor with low plasma viremia
16-1-1 ND + ND U3 deleted Non progressor with low plasma viremia
jw95-1 ND + ND U3 region (including miR-N367) Non progressor with undetectable viremia
siRNA      15-2-2 model mouse
dsnef + + + Full-length ND
sinef007 + ND ND Upstream of U3 region ND
sinef084 + ND ND Upstream of U3 region ND
sinef176 +++ +++ ++ Upstream of U3 region§ ND
sinef190 +++ +++ +++ Upstream of U3 region ND
sinef299 + ND ND U3 region (aa 83–135) ND
sinef367/miR-N367 ++ +++ ++ U3 region No weight loss
sinef468 + ND ND U3 region ND
sinef580 + ND ND U3 region ND
  1. *dsRNA to LTNPs' nef has been described (Yamamoto et al., 2002).
  2. † -, negative; +, 0 to 50 % inhibition; ++, 50 to 75% inhibition; +++, 75 to 100 % inhibition.
  3. ‡ ND, not done.
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Retrovirology

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