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Figure 7 | Retrovirology

Figure 7

From: HTLV-1 and -2 envelope SU subdomains and critical determinants in receptor binding

Figure 7

HTLV-1 SU amino terminal domain mutants. (A) H1215SU constructs were generated with the following SU amino terminal point mutations; R94A, S101A, D106A and Y114A. The abilities of these soluble H1215SU constructs to bind 293T cells were assessed by flow cytometry (gray histograms). The levels of expression of the various soluble SU subdomains are shown under each histogram. The abilities of the H1215SU mutants to interfere with (B) HTLV Env-induced cell fusion and (C) MLV(HTLV) pseudotype infection was assayed as described in Figs. 5 and 6. Data are representative of at least three independent experiments performed in duplicate. Error bars represent the standard error of the mean.

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