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Figure 5 | Retrovirology

Figure 5

From: HTLV-1 and -2 envelope SU subdomains and critical determinants in receptor binding

Figure 5

HTLV-1 and -2 SU subdomains interfere with HTLV Env-mediated cell fusion. Cell-to-cell fusion assays were performed by cocultivating fusogenic HTLV-1 Env-expressing cells with target cells expressing the Env derivatives indicated and schematically represented below each histogram. HTLV-1 Env-mediated cell fusion in the presence of target cells transfected with empty vector (Mock) yielded 200 to 1000 blue foci in 4 independent experiments and these levels were defined as 100% cell fusion. Cell fusion levels in the presence of HLTV SU mutants or the A397SU control Ampho-MLV SU subdomain is shown as percent of control. Mean fusion percentages were determined from three to four independent experiments. Error bars represent the standard error of the mean.

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