Identification of endogenous retroviral reading frames in the human genome

Retrovirology

Table 1 Genomic distribution of HERV regions

Chr.	Length (Mb)	Windows analyzed^a	Observed HERVs	Expected HERVs	χ² test^b	χ² test within chr.^c
1	246	228	654	614.7	0.0987	<0.0001
2	243	242	534	652.4	1.3E-06	<0.0001
3	199	197	581	531.1	0.0250	<0.0001
4	192	190	641	512.2	4.0E-09	<0.0001
5	181	180	446	485.3	0.0656	<0.0001
6	171	169	496	455.6	0.0513	<0.0001
7	159	157	342	423.3	4.9E-05	0.0003
8	146	145	396	390.9	0.7923	<0.0001
9	136	120	258	323.5	2.0E-04	<0.0001
10	135	135	304	364.0	1.3E-03	<0.0001
11	134	133	379	358.6	0.2695	<0.0001
12	132	132	393	355.9	0.0440	<0.0001
13	113	98	239	264.2	0.1146	<0.0001
14	105	88	205	237.3	0.0335	<0.0001
15	100	83	135	223.8	1.7E-09	<0.0001
16	90	82	101	221.1	2.6E-16	<0.0001
17	82	80	98	215.7	4.4E-16	<0.0001
18	76	77	167	207.6	0.0043	0.0001
19	64	57	259	153.7	9.4E-18	<0.0001
20	64	62	76	167.2	1.0E-12	<0.0001
21	47	36	85	97.1	0.2181	0.0588
22	49	36	55	97.1	1.7E-05	<0.0001
X	154	152	629	409.8	9.7E-29	<0.0001
Y	50	25	359	67.4	1.1E-278	<0.0001
TOTAL	3068	2905	7832	7832^d

^a Only windows overlapping with NCBI GoldenPath (release 34)
^b Single chromosomes tested against group of other chromosomes. P-values below the significance level 0.00208 (0.05/24, Bonferroni corrected) are underlined.
^c The genomic positions of HERVs were χ² tested against a random distribution using 10000 simulations for each chromosome.
^d Four additional HERV regions are located in the DR51 haplotype of the HLA region on chromosome 6 and not counted here.

ISSN: 1742-4690