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Table 2 Inhibitory effects of SCH-C and AMD3100 on HIV-1 replication in U87.CD4.CXCR4.CCR5 cells.

From: Establishment of a novel CCR5 and CXCR4 expressing CD4+ cell line which is highly sensitive to HIV and suitable for high-throughput evaluation of CCR5 and CXCR4 antagonists

  

IC50a (ng/ml)

Virus Strain

Co-receptor use

SCH-C

AMD3100

SCH-C + AMD3100

BaL

R5

39

>1000

102

NL4.3

X4

>1000

4.9

5.4

HE

R5/X4

>1000

>1000

13

  1. a Effect of AMD3100 and SCH-C on replication of laboratory HIV-1 strains BaL, NL4.3 and HE. Virus yield was monitored in the cell-free supernatant at 4–5 days after infection by p24 HIV-1 Ag ELISA.
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Retrovirology

ISSN: 1742-4690

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