Outline of one possible, chemoprophylaxis scenario. High-risk individuals would be screened by serology for HIV-1 infection. Positive individuals would be referred to a treatment center, if available. Negative individuals would be offered enrollment in the chemoprophylaxis program. Once enrolled, individuals would receive education on HIV prevention and be prescribed AZT. Every 3–6 months, these participants would be serologically re-tested. If positive, the person would be removed from the program, offered education on prevention for positives, and referred to the treatment center. If negative, AZT would be continued. Those who decline repeat testing would be taken off AZT. In this way, only those who are uninfected or recently infected would be on AZT.