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Figure 2 | Retrovirology

Figure 2

From: The sequence of the CA-SP1 junction accounts for the differential sensitivity of HIV-1 and SIV to the small molecule maturation inhibitor 3-O-{3',3'-dimethylsuccinyl}-betulinic acid

Figure 2

Effects of CA-SP1 cleavage site substitution mutations on virus particle production and sensitivity to DSB. A and C: wild type and mutant virions were produced by transfection of 293T cells, and particles were harvested and quantified by p24 ELISA (A) or reverse transcriptase assays (C). Mean values of five (panel A) or four (panel C) independent determinations are shown. B and D: assays of viral infectivity. HIV-1 and SIV were assayed for infectivity on P4-CCR5 indicator cells. Shown are the mean values of triplicate determinations after normalizing for p24 (HIV-1) or RT (SIV) in the virus stocks. Error bars represent one standard deviation.

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Retrovirology

ISSN: 1742-4690

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