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  1. Research

    Janus kinase inhibition suppresses PKC-induced cytokine release without affecting HIV-1 latency reversal ex vivo

    Despite the durable viral suppression afforded by antiretroviral therapy, HIV-1 eradication will require strategies to target latently infected cells that persist in infected individuals. Protein kinase C (PKC...

    Adam M. Spivak, Erin T. Larragoite, McKenna L. Coletti, Amanda B. Macedo, Laura J. Martins, Alberto Bosque and Vicente Planelles

    Retrovirology 2016 13:88

    Published on: 20 December 2016

  2. Research

    Ultrasensitive single-genome sequencing: accurate, targeted, next generation sequencing of HIV-1 RNA

    Although next generation sequencing (NGS) offers the potential for studying virus populations in unprecedented depth, PCR error, amplification bias and recombination during library construction have limited it...

    Valerie F. Boltz, Jason Rausch, Wei Shao, Junko Hattori, Brian Luke, Frank Maldarelli, John W. Mellors, Mary F. Kearney and John M. Coffin

    Retrovirology 2016 13:87

    Published on: 20 December 2016

  3. Research

    First Phase I human clinical trial of a killed whole-HIV-1 vaccine: demonstration of its safety and enhancement of anti-HIV antibody responses

    Vaccination with inactivated (killed) whole-virus particles has been used to prevent a wide range of viral diseases. However, for an HIV vaccine this approach has been largely negated due to inherent safety c...

    Eunsil Choi, Chad J. Michalski, Seung Ho Choo, Gyoung Nyoun Kim, Elizabeth Banasikowska, Sangkyun Lee, Kunyu Wu, Hwa-Yong An, Anthony Mills, Stefan Schneider, U. Fritz Bredeek, Daniel R. Coulston, Shilei Ding, Andrés Finzi, Meijuan Tian, Katja Klein…

    Retrovirology 2016 13:82

    Published on: 28 November 2016

  4. Research

    Membrane bound modified form of clade B Env, JRCSF is suitable for immunogen design as it is efficiently cleaved and displays all the broadly neutralizing epitopes including V2 and C2 domain-dependent conformational epitopes

    Antigenicity of HIV-1 envelope proteins (Envs) of both lab-adapted and primary isolates expressed on the cell surface rarely match with in vitro neutralization of viruses, pseudo-typed with corresponding Envs....

    Supratik Das, Saikat Boliar, Nivedita Mitra, Sweety Samal, Manish Bansal, Wayne C. Koff and Bimal K. Chakrabarti

    Retrovirology 2016 13:81

    Published on: 21 November 2016

  5. Research

    Frequency and Env determinants of HIV-1 subtype C strains from antiretroviral therapy-naive subjects that display incomplete inhibition by maraviroc

    Entry of human immunodeficiency virus type 1 (HIV-1) into cells involves the interaction of the viral gp120 envelope glycoproteins (Env) with cellular CD4 and a secondary coreceptor, which is typically one of ...

    Katharina Borm, Martin R. Jakobsen, Kieran Cashin, Jacqueline K. Flynn, Paula Ellenberg, Lars Ostergaard, Benhur Lee, Melissa J. Churchill, Michael Roche and Paul R. Gorry

    Retrovirology 2016 13:74

    Published on: 3 November 2016

  6. Research

    An HIV-1 capsid binding protein TRIM11 accelerates viral uncoating

    Several members of the TRIM family have been implicated in antiviral defense. Our previous report showed that human TRIM11 potently inhibited HIV-1 transduction by reducing the viral reverse transcripts. These...

    Ting Yuan, Weitong Yao, Kenzo Tokunaga, Rongge Yang and Binlian Sun

    Retrovirology 2016 13:72

    Published on: 13 October 2016

  7. Research

    Drug resistant integrase mutants cause aberrant HIV integrations

    HIV-1 integrase is the target for three FDA-approved drugs, raltegravir, elvitegravir, and dolutegravir. All three drugs bind at the active site of integrase and block the strand transfer step of integration....

    Janani Varadarajan, Mary Jane McWilliams, Bryan T. Mott, Craig J. Thomas, Steven J. Smith and Stephen H. Hughes

    Retrovirology 2016 13:71

    Published on: 29 September 2016

  8. Research

    Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors

    HIV-1 typically develops resistance to any single antiretroviral agent. Combined anti-retroviral therapy to reduce drug-resistance development is necessary to control HIV-1 infection. Here, to assess the utili...

    Muntasir Alam, Takeo Kuwata, Kazuya Shimura, Masaru Yokoyama, Kristel Paola Ramirez Valdez, Kazuki Tanaka, Yasuhiro Maruta, Shinya Oishi, Nobutaka Fujii, Hironori Sato, Masao Matsuoka and Shuzo Matsushita

    Retrovirology 2016 13:70

    Published on: 27 September 2016

  9. Meeting abstracts

    Proceedings of the Frontiers of Retrovirology Conference 2016

    Oral presentations

    Irena Zurnic, Sylvia Hütter, Ute Lehmann, Nicole Stanke, Juliane Reh, Tobias Kern, Fabian Lindel, Gesche Gerresheim, Martin Hamann, Erik Müllers, Paul Lesbats, Peter Cherepanov, Erik Serrao, Alan Engelman, Dirk Lindemann, Claire Da Silva Santos…

    Retrovirology 2016 13(Suppl 1):68

    Published on: 26 September 2016

    This article is part of a Supplement: Volume 13 Supplement 1

  10. Short report

    Type I interferon responses are impaired in latently HIV infected cells

    The latent HIV-1 reservoir represents the primary barrier to the eradication of HIV-1 infection. The design of novel reservoir-clearance strategies, however, is impeded in part by the inability to distinguish...

    Nischal Ranganath, Teslin S. Sandstrom, Saleh Fadel, Sandra C. Côté and Jonathan B. Angel

    Retrovirology 2016 13:66

    Published on: 9 September 2016

  11. Research

    Contribution of type W human endogenous retroviruses to the human genome: characterization of HERV-W proviral insertions and processed pseudogenes

    Human endogenous retroviruses (HERVs) are ancient sequences integrated in the germ line cells and vertically transmitted through the offspring constituting about 8 % of our genome. In time, HERVs accumulated m...

    Nicole Grandi, Marta Cadeddu, Jonas Blomberg and Enzo Tramontano

    Retrovirology 2016 13:67

    Published on: 9 September 2016

  12. Research

    Paediatric non-progression following grandmother-to-child HIV transmission

    In contrast to adult HIV infection, where slow disease progression is strongly linked to immune control of HIV mediated by protective HLA class I molecules such as HLA-B*81:01, the mechanisms by which a minori...

    M.-H. Tsai, M. Muenchhoff, E. Adland, A. Carlqvist, J. Roider, D. K. Cole, A. K. Sewell, J. Carlson, T. Ndung’u and P. J. R. Goulder

    Retrovirology 2016 13:65

    Published on: 8 September 2016

  13. Research

    The HIV-1 late domain-2 S40A polymorphism in antiretroviral (or ART)-exposed individuals influences protease inhibitor susceptibility

    The p6 region of the HIV-1 structural precursor polyprotein, Gag, contains two motifs, P7TAP11 and L35YPLXSL41, designated as late (L) domain-1 and -2, respectively. These motifs bind the ESCRT-I factor Tsg101 an...

    Susan M. Watanabe, Viviana Simon, Natasha D. Durham, Brittney R. Kemp, Satoshi Machihara, Kimdar Sherefa Kemal, Binshan Shi, Brian Foley, Hongru Li, Benjamin K. Chen, Barbara Weiser, Harold Burger, Kathryn Anastos, Chaoping Chen and Carol A. Carter

    Retrovirology 2016 13:64

    Published on: 6 September 2016

  14. Research

    Impact of APOL1 polymorphism and IL-1β priming in the entry and persistence of HIV-1 in human podocytes

    Patients of African ancestry with untreated HIV-1 infection and carrying the G1 or G2 kidney disease risk variants (Vs) at the APOL1 gene have a tenfold higher risk of developing HIV-associated nephropathy (HIVA...

    Joanna Mikulak, Ferdinando Oriolo, Federica Portale, Paolo Tentorio, Xiqian Lan, Moin A. Saleem, Karl Skorecki, Pravin C. Singhal and Domenico Mavilio

    Retrovirology 2016 13:63

    Published on: 6 September 2016

  15. Research

    Tracing HIV-1 transmission: envelope traits of HIV-1 transmitter and recipient pairs

    Mucosal HIV-1 transmission predominantly results in a single transmitted/founder (T/F) virus establishing infection in the new host despite the generally high genetic diversity of the transmitter virus populat...

    Corinna S. Oberle, Beda Joos, Peter Rusert, Nottania K. Campbell, David Beauparlant, Herbert Kuster, Jacqueline Weber, Corinne D. Schenkel, Alexandra U. Scherrer, Carsten Magnus, Roger Kouyos, Philip Rieder, Barbara Niederöst, Dominique L. Braun, Jovan Pavlovic, Jürg Böni…

    Retrovirology 2016 13:62

    Published on: 5 September 2016

  16. Research

    Impaired B cells survival upon production of inflammatory cytokines by HIV-1 exposed follicular dendritic cells

    Follicular dendritic cells (FDCs) are important components in the organization of germinal centers in lymphoid tissue where, following antigen presentation, B cells differentiate into memory B cells. The possi...

    Farideh Sabri, Alejandro Prados, Raquel Muñoz-Fernández, Rebecka Lantto, Pablo Fernandez-Rubio, Aikaterini Nasi, Sylvie Amu, Jan Albert, Enrique Garcia Olivares and Francesca Chiodi

    Retrovirology 2016 13:61

    Published on: 5 September 2016

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