Highly divergent patterns of genetic diversity and evolution in proviral quasispecies from HIV controllers

Retrovirology

Table 1 Clinical and epidemiological characteristics of HIV controllers

Patient	Birth date (year)	Gender	Exposure category	Last HIV negative test (year)	First HIV positive test (year)	Median HIV RNA VL (range)	Median CD4⁺ T cells (IQR)
PEC02	1963	Female	HET	ND	1997	<LD	1272 (1128–1425)
PEC52	1971	Female	HET	ND	1997	<LD	1391 (1343–1461)
PEC30	1983	Male	HET	ND	2009	<LD	842 (669–968)
PEC35	1980	Female	HET	2004	2011	<LD	859 (767–943)
PEC38	1976	Female	Unknown	ND	2011	<LD	1080 (1020–1230)
PEC39	1944	Female	Unknown	ND	2011	<LD	1411 (1072–1640)
EEC09	1969	Male	MSM	ND	2001	<LD (<LD–388)	932 (807–1069)
EEC11	1967	Female	HET	1989	1995	<LD (<LD–580)	1127 (1007–1301)
EEC42	1954	Female	HET	1992	1993	<LD (<LD–341)	991 (924–1118)
EEC17	1950	Female	HET	ND	2000	<LD (<LD–96)	1874 (1674–2132)
EEC18	1933	Female	HET	ND	2001	<LD (<LD–300)	694 (667–809)
EEC19	1968	Male	HET	ND	2006	<LD (<LD–73)	889 (820–973)
EEC36	1976	Female	HET	2005	2010	<LD (<LD–61)	945 (937–1157)
VC04	1965	Female	HET	ND	2008	557 (108–4407)	779 (689–811)
VC05	1964	Male	HET	ND	1991	241 (55–800)	1254 (1101–1410)
VC06	1978	Male	MSM	1999	2000	169 (<LD–405)	1093 (960–1215)
VC14	1970	Female	HET	1996	1999	106 (55–782)	702 (688–757)
VC15	1974	Female	HET	ND	2001	855 (510–2052)	699 (681–825)
VC16	1967	Male	MSM	ND	1998	240 (<LD–1683)	556 (532–608)
VC23	1971	Male	HET	2004	2008	628 (139–1842)	635 (569–671)
VC31	1963	Male	MSM	2006	2006	1558 (587–10,026)	733 (654–814)
VC32	1978	Male	MSM	2004	2005	153 (<LD–722)	641 (564–709)
VC43	1973	Female	HET	ND	2008	232 (66–864)	850 (775–911)

MSM men who have sex with men, ND not determined, VL viral load (copies/mL), LD limit of detection, IQR interquartile range, median CD4⁺ T cell (cells/µL)

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