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Table 1 Inactivation steps in virus production and the log reduction at each inactivation step
figure a

From: First Phase I human clinical trial of a killed whole-HIV-1 vaccine: demonstration of its safety and enhancement of anti-HIV antibody responses

Inactivation method

Log10 reduction

Master virus bank (Log10TCID50/ml)

Putative safety margin

AT-2

≥4.83 ± 0.26

5.64 ± 0.10

≥4.71 log units

Gamma irradiation

≥5.52 ± 0.33

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Retrovirology

ISSN: 1742-4690

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