From: Drug resistant integrase mutants cause aberrant HIV integrations
Cell type, drug concentration | Aberrant integration | Normal integration | % Aberrant integration | 1-LTR (aberrant 1-LTR) | 2-LTR (aberrant 2-LTR) | Autointegrants (aberrant circles) | Total no. of samples recovered and sequenced |
---|---|---|---|---|---|---|---|
HOS | |||||||
 No drug | 5 | 36 | 12.2 | 82 (8) | 27 (17) | 4 (66) | 287 |
 RAL IC50 | 6 | 26 | 18.7 | 75 (15) | 55 (23) | 6 (43) | 288 |
 RAL IC75 | 2 | 6 | 25 | 93 (7) | 57 (22) | 5 (55) | 288 |
PBMC | |||||||
 No drug | 10 | 103 | 8.8 | 82 (4) | 15 (1) | 0 (36) | 285 |