From: Drug resistant integrase mutants cause aberrant HIV integrations
HOS cells; drug concentration | Aberrant integration | Normal integration | % Aberrant integration | 1-LTR (aberrant 1-LTR) | 2-LTR (aberrant 2-LTR) | Autointegrants (aberrant circles) | Total no. of samples recovered and sequenced |
---|---|---|---|---|---|---|---|
No drug* | 0 | 99 | 0 | 7 (0) | 0 (0) | 1 (2) | 120 |
IC14** | 4 | 39 | 9.3 | 108 (21) | 19 (5) | 10 (56) | 288 |
IC30 | 1 | 14 | 6.6 | 102 (31) | 10 (8) | 11 (58) | 276 |
IC50 | 2 | 19 | 9.5 | 116 (18) | 28 (14) | 11 (47) | 288 |
IC60 | 2 | 19 | 9.5 | 125 (11) | 26 (10) | 12 (52) | 288 |
IC75 | 8 | 46 | 14.8 | 93 (25) | 13 (13) | 3 (57) | 287 |