Fig. 7

Recipient viruses exhibit a higher sensitivity to IFNα. a Profile of p24 antigen production measured in culture supernatants of CD8-depleted PBMCs infected with virus isolates of transmission pair T6–R6 at three different input TCID₅₀’s of 80, 160 or 320. The solid line represents replication in absence and the dashed line replication in presence of 1000 U/ml IFNα, respectively. b IFNα resistance defined as area under the curve (AUC) of p24 antigen production over a 13 day period for transmitter and recipient virus isolates on PBMCs in the presence of 1000 U/ml IFNα expressed as % of AUC in its absence. Four independent experiments indicated by different symbols are depicted. c Median IFNα resistance of four experiments between transmitter and recipient viruses was probed with a Wilcoxon matched-pairs signed rank test. Data for transmitters and recipients are indicated in red and blue, respectively