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Table 2 N332-directed heterologous NAb responses in elite neutralizer D16916

From: HIV-1 escapes from N332-directed antibody neutralization in an elite neutralizer by envelope glycoprotein elongation and introduction of unusual disulfide bonds

 

ID50 a

Foldd reduction

WTb

N332A

92BR020

1711

49

35

JRCSF

211

60

3.5

MGRM-C-026

269

70

3.9

 

T332Nc

WT (T332)

 

BG505

63

<40

>1.5

  1. a50 % inhibitory dilution (ID50)
  2. bID50 of month 14 serum tested against the 92BR020 and JRCSF (both clade B) and MGRM-C-026 (clade C) viruses and their N332A mutants
  3. cID50 of month 30 serum tested against the BG505 virus (clade A) and its T332N mutant
  4. dThe fold-reduction in neutralization as a consequence of the lack of the N332-glycan
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Retrovirology

ISSN: 1742-4690

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