Blood CD4+ T count at the time of diagnosis (cells/mm3) | p value | ||
---|---|---|---|
>350 “high-level CD4 group” (n = 9) | <350 “low-level CD4 group” (n = 15) | ||
Immunophenotypical analysis of T cells | |||
MFI CD3+/PD1+ T cells | |||
Blood | 17.8 [16.9–28] | 17.7 [16.5–22] | 0.79 |
Rectum | 30.9 [23.9–52.2] | 38.8 [27.5–44.6] | 0.88 |
p24+/CD4+ T cells (% of CD4+ T cells) | |||
Blood | 0.71 [0.26–1.45] | 0.92 [0.39–1.59] | 0.55 |
Rectum | 8.62 [2.97–16.72] | 7.23 [2.42–27.46] | 0.96 |
MFI CXCR4 in CD4+ T cells | |||
Blood | 17.78 [15.03–24] | 17.33 [16.69–21.74] | 0.72 |
Rectum | 17.44 [15.42–19.13] | 16.15 [16.02–18.61] | 0.46 |
MFI CCR5 in CD4+ T cells | |||
Blood | 42.03 [37.82–46.63] | 40.75 [38.47–46.23] | 0.97 |
Rectum | 51.01 [43.41–65.4] | 52.64 [45.02–74.96] | 1 |
Th17 cells/Treg ratio | |||
Blood | 2.9 [1.4–4.3] | 2.2 [1.5–3] | 0.64 |
Rectum | 1.4 [1.1–2.8] | 1.3 [1.1–2.5] | 0.96 |
Blood/rectum ratio of β7+ expression in CD4+ T cells | 0.9 [0.8–1.2] | 1.6 [1.3–1.8] | 0.0006 |
Blood/rectum ratio of β7+ expression in CD8+ T cells | 0.7 [0.5–1.2] | 0.8 [0.7–1] | 0.54 |
MFI CCR9 in CD4+ T cells | |||
Blood | 9.67 [9.29–10.65] | 10.13 [9.27–11.25] | 0.6 |
Rectum | 18.19 [13.93–23.51] | 20.02 [16.05–25.23] | 0.6 |
MFI CCR9 in CD8+ T cells | |||
Blood | 14.03 [13.01–20.02] | 13.73 [13.19–17.29] | 0.82 |
Rectum | 19.11 [16.41–24.14] | 16.36 [14.78–18.78] | 0.12 |
Naive CD4+ T cells (% of CD4+ T cells) | |||
Blood | 33.48 [27.55–46] | 28.63 [17.03–42.8] | 0.36 |
Rectum | 5.07 [1.96–10.35] | 4.99 [3.54–7.12] | 0.73 |
CM CD4+ T cells (% of CD4+ T cells) | |||
Blood | 38.29 [31.37–44.25] | 37.06 [26.74–48.41] | 0.97 |
Rectum | 24.38 [21.39–41.73] | 15.42 [12.75–41.48] | 0.39 |
EM CD4+ T cells (% of CD4+ T cells) | |||
Blood | 23.83 [11.89–27.31] | 22.59 [12.78–33.74] | 0.55 |
Rectum | 66.27 [53.45–71.44] | 67.99 [50.44–82.32] | 0.49 |
EMRA CD4+ T cells (% of CD4+ T cells) | |||
Blood | 4.83 [1.73–8.08] | 2.23 [0.55–4.53] | 0.22 |
Rectum | 0.61 [0.45–1.77] | 0.39 [0.12–5.2] | 0.66 |
Immunophenotypical analysis of B cells | |||
Blood naive IgD+ B cells (% of conventional B cells) | 76.6 [60.6–79.1] | 82.2 [77.3–87.6] | 0.05 |
Blood activated IgD− B cells (% of conventional B cells) | 23.1 [20.8–38.8] | 17.6 [12.4–22.4] | 0.05 |
Memory B cells (% of conventional B cells) | 5.94 [1.68–18.05] | 4.05 [2.07–5.66] | 0.34 |
Virological reservoir analysis | |||
HIV DNA load (log10 copies/millions of cells) | |||
Blood | 2.41 [2.03–2.93] | 3.48 [3.17–3.7] | 0.01 |
Rectum | 3.06 [1.93–3.63] | 3.6 [3.4–4.08] | 0.04 |