Figure 8From: A phenyl-thiadiazolylidene-amine derivative ejects zinc from retroviral nucleocapsid zinc fingers and inactivates HIV virionsWDO-217 does not cause accumulation of unprocessed Gag polyprotein. HIV-1 IIIB virions from persistently infected HuT-78 cells treated with different concentrations of compound were analysed by gel electrophoresis and immunoblotted with antibody against capsid. 1: untreated; 2: AZT (3.7 μM); 3: ritonavir (2.7 μM); 4: WDO-217 (50 μM); 5: WDO-217 (25 μM); 6: SRR-SB3 (75 μM); 7: SRR-SB3 (15 μM).Back to article page