Figure 1From: The HR2 polymorphism N140I in the HIV-1 gp41 combined with the HR1 V38A mutation is associated with a less cytopathic phenotypeThe sequence alignment of the gp41 gene from the recombinant envelope-expressing plasmids constructed from patient samples. The alignment of the gp41 ectodomain sequence (HR1 and HR2 domains) from the selected recombinant plasmids derived from three patients who failed an ENF-based treatment and carried a V38A mutation (HR1 box) with the amino acid I, N or T at position 140 (HR2 box). The Cav-1 binding domain in the HR2 region is highlighted.Back to article page