mutation | Wild-type proteases n (%) | PI resistant proteases n (%) | p-value |
---|
V362I | 3/28 (10.7) | 15/30 (50.0) | 0.002 |
A364V | 26/28 (92.9) | 10/30 (33.3) | < 0.001 |
S368N | 0/28 (0) | 9/30 (30.0) | 0.002 |
V370A | 2/28 (7.1) | 9/30 (30.0) | 0.043 |
all QVT | 2/28 (7.1) | 12/30 (40.0) | 0.005 |
- The differences in mutations that were selected with viruses with either wild-type or PI resistant proteases during the bevirimat in vitro selections are listed. Absolute frequencies and the proportion of cultures harboring the mutations are given. P-values were determined using Fisher's exact test.