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Figure 5 | Retrovirology

Figure 5

From: sCD4-17b bifunctional protein: Extremely broad and potent neutralization of HIV-1 Env pseudotyped viruses from genetically diverse primary isolates

Figure 5

HIV-1 sensitivity to sCD4- 40 -17b: independence from cellular source of virions. IMCs from strains BL01 and 89.6 were used to generate virus particles directly from transfected 293T cells; a second set of viruses was generated by single passage of the 293T-derived particles in PBMCs [30]. Both sets of particles (directly provided to us by M. Louder and J. Mascola) were analyzed for sensitivity to the agents shown. The results are plotted as the IC50 ratios of the PBMC-passaged to the 293T-derived virus particles. In each graph, the dotted line indicates a ratio of 1 (i.e., equal potency against each type of virus particle).

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Retrovirology

ISSN: 1742-4690

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