Figure 4

Comparison of neutralization breadth of sCD4- 40 -17b with broadly neutralizing monoclonal antibodies. Each pie graph shows the fraction of isolates within each IC₅₀ range for each agent tested against isolates from the indicated clades. The color-coding for IC₅₀ ranges (indicated at the top of the Figure) is the same as in Figure 3, with red<orange<yellow<white. Note that whereas for sCD4-40-17b none of the clades had isolates with IC₅₀ values in the white range (least potent), each of the MAbs had some or all isolates with IC₅₀ values in the white range for at least some clades; thus when the total isolates where evaluated for "% neutralized", the value was 100 for sCD4-40-17b but considerably less for the MAbs. The pie graphs are based on the indicated number of isolates (#) in each clade, which are the ones designated in Figure 3 with superscript letters. The sCD4-40-17b results are based on the data in Fig. 3; the MAb results are based on findings by others as follows: clade A, 6 isolates [41], 3 isolates [V. Polonis and S. Tovanabutra, personal communication]; clade B, all 12 isolates (reference panel clade B) [39]; clade C, all 12 isolates (reference panel clade C) [40]; all 3 clade D isolates [V. Polonis and S. Tovanabutra, personal communication]; all 3 clade AE and AG isolates [V. Polonis and S. Tovanabutra, personal communication].