Volume 6 Supplement 3

AIDS Vaccine 2009

Open Access

P04-35. Neutralisation activity in a geographically diverse East London cohort of HIV-1 infected patients

  • H Dreja1,
  • E O'Sullivan1,
  • C Pade1,
  • K Aubin1,
  • A Isaksen2,
  • C D'Souza2,
  • J Hand2,
  • C Orkin2,
  • W Leber3,
  • J Anderson3 and
  • Á McKnight1
Retrovirology20096(Suppl 3):P63

DOI: 10.1186/1742-4690-6-S3-P63

Published: 22 October 2009

Background

East London has a diverse population profile, where many of the inhabitants come from abroad. Consequently, they harbour viruses from the farthest corners of the globe, which partly reflect the worldwide HIV-1 epidemic. We have looked at antibody responses in this cohort and tried to establish the relationship of neutralising antibodies to viruses from the same versus different clades.

Methods

To date, >330 patients have been recruited. Neutralisation activity in plasma extracted from the treatment-naive patients was determined on TzmBl cells with a panel of 11 viruses, representing 6 different clades.

Results

Overall, the plasmas do not differ much between the groups in terms of virus neutralisation. However, we did find that clade C infected individuals neutralised the tested clade C viruses significantly better than the clade B patients. Moreover, following titrations clade C plasmas neutralised a CRF02_AG virus better than the AG samples.

Conclusion

Neutralisation activities appeared relatively sporadic and independent of genetic clades, although we suggest that clade C exposure may induce a neutralising humoral response to help control clade C and CRF02_AG challenge.

Authors’ Affiliations

(1)
Centre of Infectious Diseases, Barts and The London, Queen Mary's School of Medicine and Dentistry
(2)
Grahame Hayton Unit, The Royal London Hospital
(3)
Homerton University Hospital

Copyright

© Dreja et al; licensee BioMed Central Ltd. 2009

This article is published under license to BioMed Central Ltd.

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