Table 1 Selected HIV-1 cofactors identified in the siRNA and shRNA screens
From: siRNA and shRNA screens advance key understanding of host factors required for HIV-1 replication
Gene name | Protein function | Possible role in HIV-1 life cycle |
|---|---|---|
MED4 | mediator complex subunit | Tat-dependent activation of LTR |
MED7 | mediator complex subunit | Tat-dependent activation of LTR |
MED14 | mediator complex subunit | Tat-dependent activation of LTR |
MED28 | mediator complex subunit | Tat-dependent activation of LTR |
NUP98 | nucleoporin | nuclear import/export of viral nucleic acids and proteins |
NUP155 | nucleoporin | nuclear import/export of viral nucleic acids and proteins |
NUP210 | nucleoporin | nuclear import/export of viral nucleic acids and proteins |
GCC1 | peripheral Golgi protein | processing of viral proteins |
GOLM1 | Golgi transmembrane protein | processing of viral proteins |
GOSR2 | Golgi membrane protein | processing of viral proteins |