Table 2 Combination Index (CI) values of TFV-DP, FTC-TP and EFV combination studies in the HIV-1 RT enzymatic assay.
Drug Combinations | 32P-labeled dNTP | Ratioa | Average CI ± SDb | Degree of Synergyc |
|---|---|---|---|---|
TFV-DP+TFV-DP | dATP | 1:1 | 0.93 ± 0.07 | additive |
FTC-TP+FTC-TP | dATP | 1:1 | 1.09 ± 0.28 | additive |
|  | dCTP | 1:1 | 1.09 ± 0.25 | additive |
TFV-DP+FTC-TP | dATP | 3:1 | 0.59 ± 0.04 | synergy |
|  |  | 1:1 | 0.47 ± 0.09 | synergy |
|  |  | 1:3 | 0.47 ± 0.04 | synergy |
|  | dCTP | 3:1 | 0.60 ± 0.18 | synergy |
|  |  | 1:1 | 0.61 ± 0.11 | synergy |
|  |  | 1:3 | 0.47 ± 0.11 | synergy |
TFV-DP+EFV | dATP | 3:1 | 0.69 ± 0.01 | moderate synergy |
|  |  | 1:1 | 0.75 ± 0.04 | moderate synergy |
|  |  | 1:3 | 0.94 ± 0.08 | additive |
FTC-TP+EFV | dATP | 3:1 | 0.61 ± 0.08 | synergy |
|  |  | 1:1 | 0.70 ± 0.03 | moderate synergy |
|  |  | 1:3 | 0.81 ± 0.01 | moderate synergy |
TFV-TP+FTC-TP+EFV | dATP | 3:3:1 | 0.37 ± 0.08 | synergy |
|  |  | 1:1:1 | 0.49 ± 0.10 | synergy |
|  |  | 1:1:3 | 0.67 ± 0.18 | synergy |