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Table 3 EC50 values for RAL, MK-2048 and EVG for subtype B and C viruses cultured in cord blood mononuclear cells.

From: Comparative biochemical analysis of HIV-1 subtype B and C integrase enzymes

Subtype B

EC50 Values (μM)

Viruses

RAL (μM)

MK-2048 (μM)

EVG (μM)

   5326

0.0243 ± 0.0025

0.0072 ± 0.0021

NDa

   5331

0.0056 ± 0.0022

0.0010 ± 0.0002

0.0001 ± 0.00007

   BK 132

0.0301 ± 0.0054

0.0148 ± 0.0032

NDa

   pNL4-3

0.0082 ± 0.0013

0.0027 ± 0.0009

0.0009 ± 0.0003

   IIIb

0.0012 ± 0.0005

0.0003 ± 0.0001

0.0018 ± 0.0006

Subtype C

EC 50 Values (μM)

Viruses

RAL (μM)

MK-2048 (μM)

EVG (μM)

   Mole 03

0.0046 ± 0.0002

0.0011 ± 0.0001

NDa

   96USNG31

0.0087 ± 0.0007

0.0015 ± 0.0001

0.0008 ± 0.0006

   4742

0.0206 ± 0.0090

0.0033 ± 0.0020

0.0022 ± 0.0002

   BG-05

0.0067 ± 0.0009

0.0022 ± 0.0007

0.0008 ± 0.00004

   HB-1

0.0015 ± 0.0004

0.0007 ± 0.0005

0.0001 ± 0.00001

  1. aND = not done