Table 1 IC50 values for RAL, EVG and MK-2048 for subtype B and subtype C integrase in Mn2+-based enzymatic assays.
From: Comparative biochemical analysis of HIV-1 subtype B and C integrase enzymes
3' Processing IC50a | Strand Transfer IC50a | |||
|---|---|---|---|---|
Subtype B | Subtype C | Subtype B | Subtype C | |
RAL(μM) | 1.71(0.7-4.5) | 1.75(0.7-3.9) | 0.37(0.2-0.8) | 0.15(0.09-0.3) |
MK-2048(μM) | 0.58(0.28-1.20) | 0.19(0.09-0.39) | 0.075(0.04-0.14) | 0.08(0.03-0.2) |
EVG(μM) | 2.66(1.44-4.91) | 1.5(0.29-7.74) | 0.014(0.003-0.07) | 0.018(0.006-0.05) |