The V1-V3 region of a brain-derived HIV-1 envelope glycoprotein determines macrophage tropism, low CD4 dependence, increased fusogenicity and altered sensitivity to entry inhibitors

Table 5 Analysis of inhibition of pseudotype infection by BMS-378806

	Spl	BS	SB	Bv1v3	Bv1v2	Sv1v3	Sv1v2	Br (N283T)	Spl (T283N)	DS17	DS17 (N283T)	BaL	HxB
Br	<0.001	0.598	<0.001	0.044	<0.001	<0.001	0.002	0.620	<0.001	0.003	0.107	0.456	0.002
Spl		<0.001	0.916	<0.001	0.001	0.239	0.521	<0.001	0.162	<0.001	<0.001	<0.001	0.010
BS			<0.001	0.003	<0.001	<0.001	<0.001	0.392	<0.001	0.040	0.422	0.688	<0.001
SB				<0.001	0.039	0.390	0.610	0.002	0.323	<0.001	<0.001	0.003	0.090
Bv1v3					<0.001	0.001	0.002	0.608	<0.001	<0.001	<0.001	0.047	0.044
Bv1v2						<0.001	0.002	0.014	<0.001	<0.001	<0.001	<0.001	0.006
Sv1v3							0.456	0.044	0.115	<0.001	<0.001	<0.001	<0.001
Sv1v2								0.093	0.196	<0.001	<0.001	<0.001	0.003
Br(N283T)									0.059	0.016	0.193	0.722	0.141
Spl(T283N)										<0.001	<0.001	<0.001	<0.001
DS17											0.457	0.368	<0.001
DS17(N283T)												0.338	<0.001
BaL													<0.001

Significance (p) values were obtained with an F test; p values below 0.05 were considered significant (shown in bold) an indicate rejection of the null hypothesis of a single best fit curve for both data sets.

ISSN: 1742-4690