Table 1 Overview of CycT1 mutants used in this study.
From: Dominant negative mutant Cyclin T1 proteins inhibit HIV transcription by specifically degrading Tat
Regions | Helix# | Amino acid positions | # of clones | Activity in murine cells (*1) | ||
|---|---|---|---|---|---|---|
|  |  |  |  | >100% | 50–100% | <50% |
Region 1 | 2 | 58–65 | 29 | 4 | 14 | 11 |
Region 2 | 2 | 67–71 | 26 | 3 | 10 | 13 |
Region 3 | 3 | 88–91 | 16 | 2 | 5 | 9 |
Region 4 | 3 | 93–96 | 16 | 3 | 11 | 2 |
Region 5 | 4 | 104–108 | 5 | 0 | 0 | 5 |
Region 6 | 5 | 132–137 | 3 | 0 | 1 | 2 |
Region 7 | 5 | 139–143 | 9 | 0 | 0 | 9 |
Region 8 | 5 | 145–148 | 2 | 0 | 0 | 2 |
Region 9 | 1' | 149–152 | 9 | 3 | 4 | 2 |
total | Â | Â | 115 | 15 | 45 | 55 |