Table 2 Sequence comparison of clade B and clade C immunodominant OLPs with different frequency of CTL Responses induced in the study population
OLP Numbering | Peptide Sequences | Percent of Responders | Average Magnitude of Responders | Â | ||||
|---|---|---|---|---|---|---|---|---|
| Â | Clade B | Clade C | Location | Clade B | Clade C | Clade B | Clade C | p-value |
GAG-46 | TILKALGPAATLEEMMTA | TILRALGPGASLEEMMTA | Gag (332 – 349) | 23.33% | 11.67% | 553 | 334 | 0.022 |
POL-126 | TKIQNFRVYYRDSRDPLW | IKIQNFRVYYRDSRDPIW | Pol (933 – 950) | 16.67% | 10.00% | 535 | 358 | 0.027 |
VPR-4 | ELKREAVRHFPRPWLHGL | ELKQEAVRHFPRPWLHGL | Vpr (25 – 42) | 20.00% | 15.00% | 405 | 400 | 0.039 |
ENV-8 | LFCASDAKAYDTEVHNVW | LFCASDAKAYEKEVHNVW | gp160 (52 – 69) | 18.33% | 8.33% | 525 | 540 | N.S. |
VIF-15 | LIHLYYFDCFSESAIRNA | LIHMHYFDCFADSAIRKA | Vif (106 – 123) | 18.33% | 6.67% | 241 | 773 | N.S. |
GAG-03 | EKIRLRPGGKKKYRLKHL | EKIRLRPGGKKHYMLKHL | Gag (17 – 34) | 8.33% | 20.00% | 128 | 517 | 0.039 |
GAG-04 | GKKKYRLKHLVWASREL | GKKHYMLKHLVWASREL | Gag (25 – 41) | 11.67% | 38.33% | 911 | 670 | 0.023 |
GAG-51 | TNSATIMMQRGNFRNQRK | NSAILMQRSNFKGSKR | Gag (371 – 388) | 5.00% | 16.67% | 87 | 520 | 0.016 |
REV-03 | RTVRLIKLLYQSNPL | RAVRIIKILYQSNPY | Rev (14 – 28) | 11.67% | 21.67% | 197 | 754 | 0.013 |
POL-43 | QGWKGSPAIFQCSMTKIL | QGWKGSPAIFQSSMTKIL | Pol (306 – 323) | 10.00% | 26.67% | 268 | 672 | 0.000 |
POL-44 | IFQCSMTKILEPFRK | IFQSSMTKILEPFRA | Pol (314 – 328) | 6.67% | 21.67% | 163 | 371 | 0.010 |
POL-61 | TKALTEVVPLTEEAELEL | AKALTDIVPLTEEAELEL | Pol (441 – 458) | 6.67% | 18.33% | 460 | 723 | 0.020 |
POL-70 | MRGAHTNDVKQLTEAVQK | MRTAHTNDVKQLTEAVQK | Pol (512 – 529) | 0.00% | 26.67% | 0 | 441 | 0.002 |
POL-72 | QKIATESIVIWGKTPKFK | QKIAMESIVIWGKTPKFR | Pol (528 – 545) | 5.00% | 21.67% | 420 | 495 | 0.008 |
POL-81 | DGAANRETKLGKAGYV | DGAANRETKIGKAGYV | Pol (598 – 613) | 5.00% | 20.00% | 253 | 448 | 0.012 |
POL-82 | ETKLGKAGYVTNKGRQKV | ETKIGKAGYVTDRGRQKI | Pol (604 – 621) | 3.33% | 16.67% | 350 | 236 | 0.078 |
POL-85 | QKTELQAIHLALQDSGL | QKTELQAIYLALQDSGS | Pol (630 – 646) | 0.00% | 20.00% | 0 | 563 | 0.001 |
POL-109 | PAETGQETAYFLLKLAGR | PAETGQETAYFILKLAGR | Pol (805 – 822) | 13.33% | 18.33% | 264 | 352 | N.S. |
ENV-29 | KVSFEPIPIHYCAPAGFA | KVTFDPIPIHYCAPAGYA | gp160 (207 – 224) | 3.33% | 18.33% | 1120 | 1040 | 0.015 |
ENV-113 | YRAILHIPTRIRQGLERA | CRAIRNIPRRIRQGFEAA | gp160 (837 – 854) | 5.00% | 28.33% | 110 | 489 | 0.000 |
VIF-3 | RIRTWKSLVKHHMYISKK | KIRTWNSLVKHHMYVSRR | Vif (17 – 34) | 0.00% | 16.67% | 0 | 354 | 0.007 |