Table 1 Inhibition of HIV-1 and HIV-2 Env-mediated fusion. AMD3100 or Leu3A were added to cocultures of HIV-expressing cells and target cells at the time of co-culture and fusion was measured as described in Methods. IC50 values were derived from dose-response by fitting the data to a hyperbolic decay function.
From: Kinetic studies of HIV-1 and HIV-2 envelope glycoprotein-mediated fusion
|  | IC50 (μg/ml) for fusion at 37°C | |
|---|---|---|
| Â | AMD3100 | Leu3A |
HIV-1IIIB | 0.53 ± 0.07 | 0.3 ± 0.1 |
HIV-2ROD | >10 | 0.03 ± 0.02 |
HIV-2SBL | 0.14 ± 0.02 | 0.09 ± 0.01 |