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Volume 2 Supplement 1

2005 International Meeting of The Institute of Human Virology

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Conformational Changes in the HIV/SIV Envelope Glycoprotein

Retrovirology volume 2, Article number: S2 (2005) Cite this article

The crystallographically determined structures of unliganded, fully glycosylated SIV gp120 core (Chen et al, 2005) and of HIV gp120 core with bound CD4 and Fab 17b (Kwong et al, 1998) together allow us to visualize the conformational changes that occur in gp120 upon binding of receptor and co-receptor.

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Authors and Affiliations

  1. Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA

    Bing Chen, Erik Vogan & Stephen C Harrison

  2. Howard Hughes Medical Institute, USA

    Erik Vogan & Stephen C Harrison

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  1. Bing Chen
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  2. Erik Vogan
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  3. Stephen C Harrison
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Correspondence to Stephen C Harrison.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chen, B., Vogan, E. & Harrison, S.C. Conformational Changes in the HIV/SIV Envelope Glycoprotein. Retrovirology 2 (Suppl 1), S2 (2005). https://doi.org/10.1186/1742-4690-2-S1-S2

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  • DOI: https://doi.org/10.1186/1742-4690-2-S1-S2

Keywords

Retrovirology

ISSN: 1742-4690

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