Volume 2 Supplement 1
Mechanisms Contributing to Control of Viremia
© The Author(s) 2005
Published: 8 December 2005
Comparison of different cohorts of SIV-infected rhesus macaques that control viremia may help to identify the mechanisms that prevent progression towards AIDS. We study 3 groups of macaques able to control viremia to various extents. Group 1 was infected with live-attenuated Rev-independent SIV is able to persistently control viremia over more than 7 years. Group 2 are live-attenuated SIV-infected macaques additionally challenged with pathogenic SIVmac251 and controls the challenge to various levels (<105 copies/ml) for more than 4 years. Group 3 are SIVmac251-infected animals therapeutically immunized using DNA vectors during ART. These animals control viremia after release from ART for more than 18 months (<104 copies/ml). Animals in groups 1 and 2 developed long-lasting humoral and cellular immune responses. Animals in group 3 have persistent increases in cellular and humoral responses leading to virus containment and slower onset of disease. The understanding of the underlying mechanism leading to protective immune responses of these 3 cohorts of 'controllers' will be useful for rational vaccine design.