Volume 2 Supplement 1

2005 International Meeting of The Institute of Human Virology

Open Access

DC-SIGN as a Receptor for HTLV-1 Binding, Entry and Infection

  • Pooja Jain1,
  • Jaya Ahuja1,
  • Karan Kampani1,
  • Zafar K Khan2,
  • Suman Datta1 and
  • Brian Wigdahl1
Retrovirology20052(Suppl 1):P39

DOI: 10.1186/1742-4690-2-S1-P39

Published: 8 December 2005

Human T cell leukemia virus type 1 (HTLV-1) has been identified as the etiologic agent of adult T cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Numerous studies have demonstrated that patients diagnosed with HAM/TSP exhibit rapid activation and maturation of dendritic cells (DCs) while ATL is associated with their maturation defect. In addition to T cells, HTLV-1 is known to infect DCs. HTLV-1 infection of DCs could alter general DC function or the specific processing and/or presentation of HTLV-1-specific peptides, potentially playing a major role in the course of HTLV-1-associated disease. In this regard, we have demonstrated that an important antigen receptor on DCs, DC-SIGN serves as a receptor for HTLV-1 binding using a quantum dot-based fluorescent binding assay. We have also demonstrated that gene silencing of DC-SIGN inhibits the infection of DC in a DC/T cell co-infection system. Furthermore, expression of DC-SIGN in B cells enhances viral binding, integration, and infection. These investigations, which consider the involvement of DC surface molecules in HTLV-1 pathogenesis, are the first explorations of the intricate mechanisms that underlie the interactions between DCs and HTLV-1.

Notes

Authors’ Affiliations

(1)
Department of Microbiology and Immunology, and Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine
(2)
Department of Bioscience and Biotechnology, Drexel University

Copyright

© The Author(s) 2005

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